Welcome to the Target Protein Database
This database is an attempt to catalog in a convenient, searchable fashion all publicly available information about the identities of mammalian proteins that become covalently adducted by chemically-reactive metabolites of xenobiotic agents including drugs.

At present all entries pertain to well-identified proteins that become adducted following defined exposures to known chemical agents in vivo or in cell culture experiments (i.e, "in-life" studies only). Results from studies using enzymatic or chemical model systems are not included but may be in the future.

In general, we exclude results from studies which expose living cells to intrinsically-reactive chemicals that do not require metabolic activation to react covalently with proteins. Such experiments often use un-physiologically high concentations of the test agent, resulting in extensive adduction of large numbers of proteins, many of which may not be significantly adducted by lower fluxes of bone fide reactive metabolites.

Also excluded from this database is information about the adduction of proteins by endogenous, lipid-derived electrophiles generated under conditions of "oxidative stress" (i.e. the chemical processes of lipid peroxidation or autooxidation).

This database provides search functions that are relatively simple and intuitive, so most users can go straight to the Search page and begin searching. Additional explanations, examples and information about possible future expansions may be found on the Help page.

Finally, we invite users to tell us about their experience with the TPDB, to suggest improvements, and especially to contribute new references and data.

Reference: The reactive metabolite target protein database (TPDB) - a web-accessible resource. Robert P Hanzlik, Yakov M Koen, Bhargav Theertham, Yinghua Dong and Jianwen Fang. BMC Bioinformatics 2007, 8:95 doi:10.1186/1471-2105-8-95 http://www.biomedcentral.com/1471-2105/8/95

Last updated: April 10th, 2012.