Welcome to the Target Protein Database
This database is an attempt to catalog in a convenient, searchable fashion the publicly available information about the identities of mammalian proteins that become covalently adducted by chemically-reactive metabolites of xenobiotic agents.

At present all entries pertain to well-identified proteins that become adducted following defined exposures to known chemical agents in vivo or in cell culture experiments. Results from studies using enzymatic or chemical model systems have not been included but may be in the future.

The search functions are relatively simple and intuitive, so most users can go straight to the Search page and begin searching. Additional explanations, examples and information about possible future expansions may be found on the Help page.

TPDB was implemented as an Oracle 9i relational database. The schema of the database design is available here. The interface was written in Java Server Pages (JSP) and the Java Database Connectivity (JDBC) API was used to interface with the Oracle database. Currently the server runs on the LINUX operating system (RedHat AS3). TPDB has been tested in Internet Explorer and Firefox. Some features may not work with other browsers (e.g. Mac Safari). Uers may download free Firefox.

We invite users to tell us about their experience with the TPDB, to suggest improvements, and especially to contribute new references and data.

The reactive metabolite target protein database (TPDB) - a web-accessible resource. Robert P Hanzlik, Yakov M Koen, Bhargav Theertham, Yinghua Dong and Jianwen Fang. BMC Bioinformatics 2007, 8:95 doi:10.1186/1471-2105-8-95 http://www.biomedcentral.com/1471-2105/8/95